Nigerian Group for Blood and Marrow Transplant (NGBMT)
H/Q:Benin City
Call: +2348059953122
HSCT
Hematopoietic Stem cell transplantation(HSCT) and research is a modern therapy to cure or ameliorate some malignant and non – malignant diseases. It involves the destruction of stem cells in the marrow of a patient, collection/manipulation of stem cells from a normal donor which is then transplanted to cure  the patient.
Nigeria (University of Benin Teaching Hospital Stem Cell Transplant Center)in 2011 performed the First Successful HSCT for a-7year-old patient with Sickle Cell Disease (SCD), and in the year 2013 performed a second successful HSCT for a 14-year-old patient with SCD. The first patient is 2yrs post-transplant and he is medically sound while the second patient is over 120 days post transplant and he is also medically sound.Transplant for malignant diseases  is better after the first complete remission while those with iron overload e.g hemoglobinopathy will benefit from iron chelating. Patients  with HbSS will benefit from use of Hydroxyurea pre -transplant.


INDICATIONS FOR HSCT

-Hemoglobinopathy  eg HbSS,Thal etc

-Adult &Pediatric leukaemias(ALL,AML,CLL etc

-Lymphomas

- Hereditary marrow failure syndrome e.g Fanconi anaemia,Diamond Blackfan syndrome etc

-Multiple myeloma

-Primary Amyloidosis

-Solid tumors e.g Breast cancer,Ewing Sarcoma,neuroblastoma,ovarian cancer,osteosarcoma,renal cell cancer,melanoma etc

-Autoimmune diseases e.g Connective tissue disorders(multiple sclerosis,Systemic Lupus Erythromatosis,Arthritis,inflammatory bowel disease,vasculitis,mystenia gravis,ITP etc

-Aplastic anaemia

-Tissue regeneration in Adult  with stem cell research e.g Cardiac repair with cardiomyocytes,Osteocytes and chondrocytes  derived from MSC for orthopedic application,Embryonic stem cells for insulin producing cells in DM,Neural stem cells for CNS disorders.
-Myelodysplastic syndrome
-Severe combined immunodeficiency syndrome e,g SCIDS
-Inborn errors  of metabolism e.g muco-polysaccharidosis(MPS),Leucodystrophy, osteopetrosis etc.
-Human Immunodeficiency Virus (HIV) with CCR5 donors (controversial)first successful transplant was a patient with leukemia and HIV
-Solid tumors

SELECTION AND PREPARATION OF PATIENTS/DONOR

Selection is based on the following

-Type of HSCT (Autologous or Allogeneic )

-Age of patient/donor

-Stage of disease,

-Prognosis

-Availability of HLA matched donor (serology Human lymphocyte antigen(HLA)  preferable 6/6,molecular HLA 10/12 or 12/12.)

-Other basic investigations e.g CT scan, Chest x-ray, viral studies(HIV, Hepatitis B and C,CMV),TB screening, blood culture, etc.Usually chemotherapy/Radiotherapy especially for malignant diseases e.g as induction regimen.

ACCOUNTS 

UBTH Stem Cell Transplant Account

Account Name: LAB

Account  No: 1000625413

Bank: UBA

BBMT Account

Account Name: BBMT Transplant Society

Account No: 5542014318

Bank:ECOBANK
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