challenges of setting up stem cell transplant center in a poor resources and developing country (Nigeria)
Nosakhare Bazuaye, ,Douglas I,Ademola,Ben Nwogoh,,Awodu O.A
Hematologist (Benin, NG)
Abstract Objectives: Hematopoietic stem cell transplantation(HSCT) is an approved therapy for malignant and non-malignant diseases. Nigeria with a population of 150 million like most developing countries requires HSCT that will be affordable and available. Challenges include: Lack of Trained personnel:-Training of personnel at the Basel Hospital commenced in 2009 under the supervision of Prof.Alois Gratwohl but only a Hematologist, two Nurses ,and a laboratory Scientist have been trained. There are plans for personnel from Nigeria to be trained in Switzerland and experts from switzerland to visit Nigeria. Poor infrastructure / Equipment:four isolation room unit was built with hyperfilteration and high pressure single machines. However only basic equipment needed for Allogeneic transplantation are available with plans to procure equipment for autologous transplant. A generating plant with an inverter battery was provided as an alternative for power supply Selection of donor and patients:Sickle cell Anaemia(SCA) was the first group of patient selected for HSCT (first HSCT was 28th September 2011) because it accounts for 3% of Nigerian population and will attract funding from the Federal Government. HLA typing is currently done in Basel Hospital. Conditioning:Reduced intensity conditioning (RIC) (FLU/BU)was used for our patient. Stem Cell Harvesting: Bone marrow was the
source of stem cell for the patient with a total of 800mls marrow plus
100mls anticoagulant. The unit had no equipment to separate CD34 cells
and patient developed a transient hypertensive crises with prolonged
APTT controlled with Methyl Dopa and protamine SUBMITTED ABSTRACTS OF THE 1ST CONFERENCE/WORKSHOP OF THE NGBMT HELD IN BENIN CITY. |
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